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Active Giant Cell Vasculitis Diagnosis with 68Ga PSMA PET/CT Imaging

10.4274/mirt.galenos.2019.90532

  • Muhammet Sait Sağer
  • Seçkin Bilgiç
  • Lebriz Uslu
  • Sertaç Asa
  • Güneş Sağer
  • Kerim Sönmezoğlu

Received Date: 13.09.2019 Accepted Date: 17.12.2019 Mol Imaging Radionucl Ther 2021;30(1):57-59

Vasculitis is a multisystem disease characterized by inflammation with infiltration of leukocytes into the blood vessels. Giant cell arteritis (GCA) is the most common form of vasculitis that mostly affects medium- and large-sized arteries. 18Fluorine-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is increasingly used to diagnose inflammation of large arteries in GCA. Galium-68 prostate-specific membrane antigen (PSMA) PET/CT has a vital role in the assessment of patients with prostate cancer for recurrence and metastasis of the disease. Various benign and non-prostate malignant conditions may give rise to increased PSMA uptake. Herein, we demonstrate that PSMA uptake can be seen in GCA.

Keywords: Vasculitis, GCA, PSMA PET, 18F-FDG PET

Ethics

Informed Consent: Was obtained from the patient.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Concept: M.S.S., Design: M.S.S., Data Collection or Processing: K.S., Literature Search: S.B., S.A., Writing: G.S., L.U.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.

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  1. Chun AR, Jo HM, Lee SH, Chun HW, Park JM, Kim KJ, Jung CH, Mok JO, Kang SK, Kim CH, Kim BY. Risk of malignancy in thyroid incidentalomas identified by fluorodeoxyglucose-positron emission tomography. EndocrinolMetab (Seoul) 2015;30:71-77.
  2. Giovacchini G, Giovannini E, Riondato M, Ciarmiello A. PET/CT With 68Ga-PSMA in Prostate Cancer: Radiopharmaceutical Background and Clinical Implications. Curr Radiopharm 2018;11:4-13.
  3. Malik D, Kumar R, Mittal BR, Singh H, Bhattacharya A, Singh SK. 68Ga-Labeled PSMA Uptake in Nonprostatic Malignancies: Has the Time Come to Remove “PS” From PSMA? Clin Nucl Med 2018;43:529-532.
  4. Treglia G, Mattoli MV, Leccisotti L, Ferraccioli G, Giordano A. Usefulness of whole-body fluorine-18-fluorodeoxyglucose positron emission tomography in patients with large-vessel vasculitis: a systematic review. Clin Rheumatol 2011;30:1265-1275.
  5. Balink H, Bennink RJ, van Eck-Smit BL, Verberne HJ. The role of 18F-FDG PET/CT in large-vessel vasculitis: appropriateness of current classification criteria? Biomed Res Int 2014;2014:687608.